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Thia‐Michael Addition: An Emerging Strategy in Organic Synthesis
Asian Journal of Organic Chemistry ( IF 2.7 ) Pub Date : 2018-02-08 , DOI: 10.1002/ajoc.201700609
Preeti Wadhwa 1 , Anupreet Kharbanda 1 , Anuj Sharma 1
Affiliation  

The thia‐Michael addition reaction has been demonstrated to be a highly powerful tool in organic synthesis. Indeed, the influential nature of this reaction has been well‐established in the fields of medicinal chemistry, catalysis, drug discovery, and materials science. The emergence of numerous synthetic strategies that take advantage of thia‐Michael addition reactions of electron‐deficient alkenes has unleashed countless opportunities for the design and synthesis of diverse biologically relevant organosulfur compounds. However, despite myriad potential synthetic applications, there has not been any exclusive reviews of the thia‐Michael addition reaction. Therefore, this Focus Review plots the journey of the thia‐Michael addition reaction in organic synthesis, and is categorized according to catalyzed and catalyst‐free thia‐Michael addition reactions.

中文翻译:

Thia-Michael加成法:有机合成中的新兴策略

Thia-Michael加成反应已被证明是有机合成中非常有效的工具。确实,该反应的影响力性质已经在药物化学,催化,药物发现和材料科学领域得到了公认。利用缺乏电子的烯烃的噻吩-迈克尔加成反应的众多合成策略的出现,为设计和合成各种生物学相关的有机硫化合物释放了无数的机会。然而,尽管有大量潜在的合成应用,但对硫杂-迈克尔加成反应还没有任何专门的评论。因此,本《焦点评论》绘制了有机合成中噻吩迈克尔加成反应的历程,
更新日期:2018-02-08
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