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Reshaping silica particles: Mesoporous nanodiscs for bimodal delivery and improved cellular uptake
Chemical Engineering Journal ( IF 15.1 ) Pub Date : 2018-01-11 , DOI: 10.1016/j.cej.2018.01.059
Valentina Giglio , Silvia Varela-Aramburu , Leana Travaglini , Federica Fiorini , Peter H. Seeberger , Laura Maggini , Luisa De Cola

The role played by the shape of mesoporous silica nanoparticles has been investigated for intra- and extracellular delivery. Specifically, we have developed the bottom-up synthesis of flat disc-shaped mesoporous silica nanoparticles, the Nanodiscs (NDs). Due to their peculiar shape and large porous system, NDs present a higher cellular uptake than commonly investigated spherical mesoporous nanoparticles. Moreover, NDs are able to efficiently perform exhaustive delivery of their therapeutic cargo when loaded with the anticancer drug Doxorubicin and administered in vitro to cancerous HeLa cells. Thanks to their aspect ratio, NDs can also be readily assembled into well-organized monolayers to be employed in HeLa cells adhesion experiments upon preliminary functionalization with a specific targeting ligand. In these conditions NDs are able to deliver a hydrophobic dye to adhered cells via the highly accessible vertically aligned pores and their flat surface that ensures optimal cell contact. This initial investigation on the performance of NDs in both intra- and extracellular delivery activities suggests the great potential of these particles.



中文翻译:

重塑二氧化硅颗粒:用于双峰递送和改善细胞吸收的中孔纳米圆盘

已经研究了介孔二氧化硅纳米颗粒形状对细胞内和细胞外递送的作用。具体而言,我们已经开发出了平盘形介孔二氧化硅纳米粒子的自下而上的合成方法,即Nanodiscs(NDs)。由于其独特的形状和较大的多孔系统,NDs比通常研究的球形介孔纳米颗粒具有更高的细胞吸收率。此外,当NDs装载抗癌药阿霉素并体外施用于癌性HeLa细胞时,能够有效地彻底运送其治疗药物。由于其纵横比,ND当用特定的靶向配体进行初步功能化时,也可以容易地将其组装成组织良好的单层以用于HeLa细胞粘附实验。在这些条件下,ND能够通过高度可及的垂直排列的孔及其平坦的表面将疏水性染料传递到粘附的细胞上,从而确保最佳的细胞接触。这项关于ND在细胞内和细胞外递送活动中的性能的初步研究表明,这些颗粒具有巨大的潜力。

更新日期:2018-01-11
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