A series of new dehydroacetic acid chalcone-1,2,3-triazole hybrids as potential antimicrobial agents was designed, synthesized and characterized by FTIR, NMR and HRMS spectral techniques. All the synthesized compounds were screened in vitro against four bacterial strains (Staphylococcus epidermidis, Bacillus subtilis, Escherichia coli and Pseudomonas aeruginosa) and two fungal strains (Aspergillus niger and Candida albicans). The antimicrobial results indicated that some of the compounds showed remarkable activities comparable to the standard drugs. Most of the compounds exhibited better efficacy compared to the DHA, which is itself an antimicrobial agent. The synergistic effect in biological activity was observed when DHA, chalcone and 1,2,3-triazole are conjugated. The molecular modeling studies of compound 5j into E. coli topoisomerase II DNA gyrase B were also performed.

通过FTIR，NMR和HRMS光谱技术，设计，合成和表征了一系列新型的脱氢乙酸查耳酮-1,2,3-三唑杂化物。所有合成的化合物在体外筛选了4种细菌菌株（表皮葡萄球菌，枯草芽孢杆菌，大肠杆菌和铜绿假单胞菌）和2种真菌菌株（黑曲霉和白色念珠菌）。）。抗菌结果表明，某些化合物显示出与标准药物相当的活性。与DHA本身相比，大多数化合物表现出更好的功效，DHA本身就是一种抗菌剂。当DHA，查尔酮和1,2,3-三唑缀合时，观察到了对生物活性的协同作用。还进行了将化合物5j转化为大肠杆菌拓扑异构酶II DNA促旋酶B的分子模型研究。