The peripheral blood eosinophil count might help identify those patients with chronic obstructive pulmonary disease (COPD) who will experience fewer exacerbations when taking inhaled corticosteroids (ICS). Previous post-hoc analyses have proposed eosinophil cutoffs that are both arbitrary and limited in evaluating complex interactions of treatment response. We modelled eosinophil count as a continuous variable to determine the characteristics that determine both exacerbation risk and clinical response to ICS in patients with COPD.

中文翻译：

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慢性阻塞性肺疾病患者恶化风险和对布地奈德反应的预测因素：三项随机试验的事后分析。

外周血嗜酸性粒细胞计数可能有助于识别那些在服用吸入性皮质类固醇 (ICS) 时病情恶化较少的慢性阻塞性肺病 (COPD) 患者。以前的事后分析提出了嗜酸性粒细胞截止值，这些截止值在评估治疗反应的复杂相互作用时既随意又有限。我们将嗜酸性粒细胞计数建模为一个连续变量，以确定决定 COPD 患者 ICS 恶化风险和临床反应的特征。