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Dehydration of Amides to Nitriles under Conditions of a Catalytic Appel Reaction
Organic Letters ( IF 5.2 ) Pub Date : 2018-01-10 00:00:00 , DOI: 10.1021/acs.orglett.7b03862
Sergei A. Shipilovskikh 1 , Vladimir Yu. Vaganov 1 , Elena I. Denisova 1 , Aleksandr E. Rubtsov 1 , Andrei V. Malkov 2, 3
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A highly expedient protocol for a catalytic Appel-type dehydration of amides to nitriles has been developed that employs oxalyl chloride and triethylamine along with triphenylphosphine oxide as a catalyst. The reactions are usually complete in less than 10 min with only a 1 mol % catalyst loading. The reaction scope includes aromatic, heteroaromatic, and aliphatic amides, including derivatives of α-hydroxy and α-amino acids.

中文翻译:

催化Appel反应条件下酰胺脱水成腈

已经开发了一种高度便利的将酰胺催化Appel型脱水为腈的方案,该方案采用草酰氯和三乙胺以及三苯基氧化膦作为催化剂。反应通常在少于10分钟的时间内完成,催化剂负载量仅为1 mol%。反应范围包括芳族,杂芳族和脂族酰胺,包括α-羟基和α-氨基酸的衍生物。
更新日期:2018-01-10
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