Using metal organic precursors in materials synthesis remains a challenge due to their high moisture susceptibility. In this work, we describe a facile methodology for the synthesis of Gd₂O₃-based contrast agents from two new gadolinium-based complexes. [Gd(PyTFP)₄] (PyH) 1 (PyTFP = C₈H₅NOF₃, Py = C₅H₅N) and [Gd(DMOTFP)₃Py] 2 (DMOTFP = C₈H₇NO₂F₃) were synthesized via a classical ligand exchange reaction of [Gd{N(SiMe₃)₂}₃] under inert conditions. As a result, X-ray diffraction analysis revealed a distorted square antiprismatic coordination and an augmented triangular prismatic arrangement of ligands around gadolinium atoms in 1 and 2, respectively. It also showed that 1 is an anionic complex of formula [Gd(PyTFP)₄](PyH), while a neutral tris-compound, [Gd(DMOTFP)₃Py], was obtained as a pyridine adduct in 2. Fast and reproducible microwave-assisted decomposition of 1 and 2 provided homogeneous Gd(OH)₃ nanorods at mild temperature without using any surfactant or capping reagent. As-synthesized nanorods were easily transformed into a cubic phase of Gd₂O₃ nanoparticles by thermal treatment under ambient conditions. The magnetic measurement showed the typical paramagnetic behavior of the Gd₂O₃ nanoparticles (NPs). The cytotoxicity profile demonstrates the biocompatibility and negligible toxicity of the as-synthesized nanoprobes. The suggested approach provides a new class of gadolinium-based precursors which allows facile synthesis of highly crystalline Gd₂O₃ NPs.

中文翻译：

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空气稳定的Pre前体，用于微波辅助合成的用于磁共振成像的Gd ₂ O ₃纳米造影剂。

由于金属易受潮性高，在材料合成中使用金属有机前驱物仍然是一个挑战。在这项工作中，我们描述了一种从两种新的based基复合物合成Gd ₂ O ₃基造影剂的简便方法。[Gd（PyTFP）₄ ]（PyH）1（PyTFP = C ₈ H ₅ NOF ₃，Py = C ₅ H ₅ N）和[Gd（DMOTFP）₃ Py] 2（DMOTFP = C ₈ H ₇ NO ₂ F ₃）是通过[Gd {N（SiMe ₃）₂ } ₃ ]在惰性条件下。结果，X射线衍射分析显示扭曲的方形反棱柱配位和分别在1和2中的atoms原子周围的配体增加了三角棱柱形排列。还显示出1是式[Gd（PyTFP）₄ ]（PyH）的阴离子络合物，而在2中以吡啶加合物的形式获得了中性三元化合物[Gd（DMOTFP）₃ Py] 。快速和可重现的微波辅助分解1和2提供了均一的Gd（OH）₃纳米棒在温和的温度下，不使用任何表面活性剂或封端剂。通过在环境条件下进行热处理，可以将合成后的纳米棒轻松转变为Gd ₂ O ₃纳米颗粒的立方相。磁性测量显示了Gd ₂ O ₃纳米颗粒（NPs）的典型顺磁行为。细胞毒性概况证明了合成纳米探针的生物相容性和可忽略的毒性。建议的方法提供了新的一类基于lin的前体，它可以轻松合成高度结晶的Gd ₂ O ₃ NP。