The blood brain barrier is the main obstacle to delivering diagnostic and therapeutic agents to the diseased sites of brain. It is still of great challenge for the combined use of focused ultrasound (FUS) and theranostic nanotechnology to achieve noninvasive and localized delivery of chemotherapeutic drugs into orthotopic brain tumor. In this work, a unique theranostic nanoplatform for highly efficient photoacoustic imaging‐guided chemotherapy of brain tumor both in vitro and in vivo, which is based on the utilization of hollow mesoporous organosilica nanoparticles (HMONs) to integrate ultrasmall Cu_2−xSe particles on the surface and doxorubicin inside the hollow interior, is synthesized. The developed multifunctional theranostic nanosystems exhibit tumor‐triggered programmed destruction due to the reducing microenvironment‐responsive cleavage of disulfide bonds that are incorporated into the framework of HMONs and linked between HMONs and Cu_2−xSe, resulting in tumor‐specific biodegradation and on‐demand drug‐releasing behavior. Such tumor microenvironment‐responsive biodegradable and biocompatible theranostic nanosystems in combination with FUS provide a promising delivery nanoplatform with high performance for orthotopic brain tumor imaging and therapy.

中文翻译：

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超声增强可生物降解多功能纳米平台在影像引导下脑肿瘤治疗中的应用

血脑屏障是向脑部患病部位输送诊断和治疗药物的主要障碍。对于聚焦超声（FUS）和治疗学纳米技术的结合使用，以实现化学治疗药物向原位脑肿瘤的无创和局部递送，仍然是巨大的挑战。在这项工作中，高效率的光声成像的唯一治疗诊断纳米平台-引导在体外和体内脑肿瘤，这是基于中空介孔有机二氧化硅纳米颗粒（HMONs）以集成超小Cu的利用化疗_{2- X}合成了表面上的硒颗粒和中空内部的阿霉素。发达的多功能治疗法纳米系统表现出肿瘤触发的程序性破坏，这是由于减少了二硫键的微环境响应性裂解，该二硫键已整合到HMON的框架中并连接在HMON和Cu _{2- x} Se之间，导致肿瘤特异性的生物降解和降解。要求药物释放行为。此类肿瘤微环境响应性可生物降解和生物相容性治疗学纳米系统与FUS结合可为原位脑肿瘤成像和治疗提供前景广阔的高性能纳米平台。