Phyllodulcin, an isocoumarin derivatives and well-known natural sweetener derived from Hydrangea macrophylla var, was evaluated for its roles in diabetes-related metabolic and genetic changes by regulating glucose homeostasis in the liver. C57BL/KsJ-db/db mice received 20 mg/kg body weight (b.w.) stevioside (SVS 20), 10 mg/kg b.w. phyllodulcin (P 10), or 20 mg/kg b.w. phyllodulcin (P 20) for four weeks. Water and food intake were significantly lower in the phyllodulcin supplemented group compared with the diabetic group. Phyllodulcin supplementation suppressed the levels of fasting blood glucose, HbA1c, and plasma and hepatic triglyceride level. Phyllodulcin improved hepatic lipogenesis, while also suppressing inflammation and oxidative stress. Phyllodulcin inhibited hepatic fibrosis and regulated liver glucose homeostasis. Thus, these results indicate the potential of phyllodulcin to serve as a therapeutic agent to improve global hepatic function and metabolic abnormalities of diabetic conditions and the necessity to be better explored.

香豆素，异香豆素衍生物和著名的天然甜味剂，衍生自八仙花通过调节肝脏中的葡萄糖稳态来评估var在糖尿病相关的代谢和遗传变化中的作用。C57BL / KsJ-db / db小鼠接受20 mg / kg体重（bw）甜菊糖苷（SVS 20），10 mg / kg bw phyllodulcin（P 10）或20 mg / kg bw phyllodulcin（P 20），持续4周。叶绿素补充组的水和食物摄入量显着低于糖尿病组。补充叶绿素抑制了空腹血糖，HbA1c水平以及血浆和肝甘油三酯水平。毛绿素改善了肝脏的脂肪生成，同时还抑制了炎症和氧化应激。毛绿素抑制肝纤维化并调节肝葡萄糖稳态。因此，