Selective detection of biothiols holds prime importance owing to the role of varied concentrations of biothiols in various diseases, thus demanding extensive research for developing materials toward selective sensing. In this study, we targeted postsynthetic modification (PSM) approach for imparting desired functionality to chemically stable UiO-66-NH₂ metal–organic framework, which exhibits highly selective sensing toward biothiols. The appended dinitrobenzenesulfonyl group reacts with biothiols via chemidosimetric approach. As a consequence, the probe exhibits a turn on response, which holds immense importance for facile biological studies.

中文翻译：

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通过金属化学计量学方法在水中基于金属-有机骨架的生物硫醇选择性传感

由于各种疾病中不同浓度的生物硫醇的作用，选择性检测生物硫醇具有最重要的意义，因此需要广泛的研究以开发用于选择性传感的材料。在这项研究中，我们针对合成后修饰（PSM）方法赋予化学稳定的UiO-66-NH ₂金属-有机骨架所需的功能，该骨架对生物硫醇表现出高度的选择性。附加的二硝基苯磺酰基通过化学计量学方法与生物硫醇反应。结果，该探针表现出开启响应，这对于简便的生物学研究具有极其重要的意义。