AbstractA carbon electrode modified with the ionic liquid octylpyridinium hexafluorophosphate and copper hydroxide nanoparticles was employed in an electrochemical assay for simultaneous determination of captopril (CPT) and hydrochlorothiazide (HCT). The electrode showed two well-defined oxidation peaks for CPT (at 0.22 V) and HCT (at 0.73 V, both vs. Ag/AgCl) at pH 8.0 using square wave voltammetry. Calibration plots are linear in the concentration ranges of 0.7–70 µM (CPT) and 3–600 μM (HCT), with detection limits of 12 and 60 nM, respectively. The electrode was repeatedly applied to simultaneous determination of CPT and HCT in pharmaceutical formulation without showing any fouling. Graphical abstractApplication of carbon ionic liquid electrode (CILE) modified with Cu(OH)2 nanoparticles (Cu(OH)2NP/CILE) for the simultaneous determination of captopril (CPT) and hydrochlorothiazide (HCT) in pharmaceutical formulation is presented.

中文翻译：

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氢氧化铜纳米粒子修饰碳离子液体电极同时测定卡托普利和氢氯噻嗪

摘要 采用离子液体六氟磷酸辛基吡啶鎓和氢氧化铜纳米颗粒修饰的碳电极用于电化学测定，用于同时测定卡托普利 (CPT) 和氢氯噻嗪 (HCT)。使用方波伏安法，电极在 pH 8.0 下显示了 CPT（0.22 V）和 HCT（0.73 V，均与 Ag/AgCl）的两个明确定义的氧化峰。校准图在 0.7–70 µM (CPT) 和 3–600 µM (HCT) 的浓度范围内呈线性，检测限分别为 12 和 60 nM。该电极被反复用于同时测定药物制剂中的 CPT 和 HCT，而没有显示出任何污染。