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Copper-Catalyzed Radical Difluoroalkylation and Redox Annulation of Nitroalkynes for the Construction of C2-Tetrasubstituted Indolin-3-ones
Organic Letters ( IF 5.2 ) Pub Date : 2018-01-10 00:00:00 , DOI: 10.1021/acs.orglett.7b03678
Wenqiang Fu 1 , Qiuling Song 1
Affiliation  

An efficient and convenient method with wide applicability for the synthesis of C2-tetrasubstituted indolin-3-ones via copper-catalyzed redox cycloisomerization of nonprefunctionalized nitroalkynes has been developed. This protocol features simple operation, readily available starting materials, good functional group tolerance, broad scope, and diboron as the reductant.

中文翻译:

铜催化的硝基二氟烷基化和硝基炔的氧化还原环化反应,用于构建C2-四取代的吲哚-3-酮。

通过铜的非预官能化硝基炔烃的氧化还原环异构化合成C2-四取代的吲哚-3-酮的一种有效,方便的方法,具有广泛的适用性。该方案的特点是操作简单,原料易得,官能团耐受性好,适用范围广,并且乙硼烷可作为还原剂。
更新日期:2018-01-10
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