Risk of pancreatic cancer associated with family history of cancer and other medical conditions by accounting for smoking among relatives,International Journal of Epidemiology

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Risk of pancreatic cancer associated with family history of cancer and other medical conditions by accounting for smoking among relatives
International Journal of Epidemiology ( IF 7.7 ) Pub Date : 2018-01-10 , DOI: 10.1093/ije/dyx269
E Molina-Montes ₁ , P Gomez-Rubio ₁ , M Márquez ₁ , M Rava ₁ , M Löhr ₂ , C W Michalski _{3,

4} , X Molero ₅ , A Farré ₆ , J Perea ₇ , W Greenhalf ₈ , L Ilzarbe ₉ , M O'Rorke ₁₀ , A Tardón ₁₁ , T Gress ₁₂ , V M Barberà ₁₃ , T Crnogorac-Jurcevic ₁₄ , E Domínguez-Muñoz ₁₅ , L Muñoz-Bellvís ₁₆ , J Balsells ₅ , E Costello ₈ , J Huang ₂ , M Iglesias ₉ , J Kleeff _{3,

17} , Bo Kong ₃ , J Mora ₆ , L Murray ₁₀ , D O'Driscoll ₁₈ , I Poves ₉ , A Scarpa ₁₉ , W Ye ₂ , M Hidalgo ₂₀ , L Sharp _{18,

21} , A Carrato ₂₂ , F X Real ₂₃ , N Malats ₁ ,

Affiliation

Spanish National Cancer Research Center (CNIO), Genetic and Molecular Epidemiology Group, Madrid, and CIBERONC, Spain.
Karolinska Institutet and University Hospital, Gastrocentrum, Stockholm, Sweden.
Technical University of Munich, Department of Surgery, Munich, Germany.
University of Heidelberg, Department of Surgery, Heidelberg, Germany.
Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute (VHIR), Universitat Autònoma de Barcelona, Barcelona, and CIBEREHD, Spain.
Hospital de la Santa Creu i Sant Pau, Department of Gastroenterology, Barcelona, Spain.
University Hospital 12 de Octubre, Department of Surgery, Madrid, Spain.
Royal Liverpool University Hospital, Department of Molecular and Clinical Cancer Medicine, Liverpool, UK.
Hospital del Mar-Parc de Salut Mar, Barcelona, Spain.
Queen's University Belfast, Centre for Public Health, Belfast, UK.
Instituto Universitario de Oncología del Principado de Asturias, Department of Medicine, Oviedo, and CIBERESP, Spain.
University Hospital of Giessen and Marburg, Department of Gastroenterology, Marburg, Germany.
General University Hospital of Elche, Molecular Genetics Laboratory, Elche, Spain.
Barts Cancer Institute, Centre for Molecular Oncology, Queen Mary University of London, London, UK.
University Clinical Hospital of Santiago de Compostela, Department of Gastroenterology, Santiago de Compostela, Spain.
Salamanca University Hospital, General and Digestive Surgery Department, Salamanca, Spain.
Martin-Luther-University Halle-Wittenberg, Department of Visceral, Vascular and Endocrine Surgery, Halle (Saale), Germany.
National Cancer Registry Ireland and HRB Clinical Research Facility, University College Cork, Cork, Ireland.
ARC-Net Centre for Applied Research on Cancer and Department of Pathology and Diagnostics, University and Hospital Trust of Verona, Verona, Italy.
Madrid-Norte-Sanchinarro Hospital, Madrid, Spain.
Newcastle University, Institute of Health and Society, Newcastle upon Tyne, UK.
Ramón y Cajal University Hospital, Department of Oncology, IRYCIS, Alcala University, Madrid, and CIBERONC, Spain.
Spanish National Cancer Research Centre (CNIO), Epithelial Carcinogenesis Group, Madrid, Universitat Pompeu Fabra, Departament de Ciències Experimentals i de la Salut, Barcelona, and CIBERONC, Spain.

Family history (FH) of pancreatic cancer (PC) has been associated with an increased risk of PC, but little is known regarding the role of inherited/environmental factors or that of FH of other comorbidities in PC risk. We aimed to address these issues using multiple methodological approaches.

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