Basal cell carcinoma (BCC) is the most common form of human cancer, with a continually increasing annual incidence in the United States. When diagnosed early, the majority of BCCs are readily treated with office-based therapy, which is highly curative. In these evidence-based guidelines of care, we provide recommendations for the management of patients with BCC, as well as an in-depth review of the best available literature in support of these recommendations. We discuss biopsy techniques for a clinically suspicious lesion and offer recommendations for the histopathologic interpretation of BCC. In the absence of a formal staging system, the best available stratification based on risk for recurrence is reviewed. With regard to treatment, we provide recommendations on treatment modalities along a broad therapeutic spectrum, ranging from topical agents and superficially destructive modalities to surgical techniques and systemic therapy. Finally, we review the available literature and provide recommendations on prevention and the most appropriate follow-up for patients in whom BCC has been diagnosed.

基底细胞癌（BCC）是人类癌症的最常见形式，在美国，每年的发病率不断增加。早期诊断后，大多数BCC都可以通过基于办公室的疗法进行治疗，这种疗法具有很高的治愈性。在这些基于证据的护理指南中，我们为BCC患者的治疗提供了建议，并对支持这些建议的现有最佳文献进行了深入综述。我们讨论了临床可疑病变的活检技术，并为BCC的组织病理学解释提供了建议。在没有正式的分期系统的情况下，将根据复发风险评估最佳的可用分层。关于治疗，我们就广泛的治疗范围提供治疗方式方面的建议，从局部用药和表面破坏性方法到手术技术和全身疗法，应有尽有。最后，我们回顾了现有文献并针对已诊断出BCC的患者提供了预防和最合适的随访建议。