Antimicrobial resistance (AMR) and the associated morbidity and mortality due to bacterial pathogens have been increasing globally to alarming levels. The World Health Organization (WHO) has called for global action on AMR, supported worldwide by governments, health ministries and health agencies. Many potential solutions to stem AMR are being discussed and implemented. These include increases in antimicrobial stewardship, investment in research and development to design new classes of antibiotics, and reduction of antibiotic use in rearing of livestock. However, vaccines as tools to reduce AMR have historically been under-recognized in these discussions, even though their effectiveness in reducing disease and AMR is well documented. This review article seeks to highlight the value of vaccines as an additional modality to combat AMR globally, using select examples. It also will provide perspectives on how vaccines could be more effectively used in this effort.

中文翻译：

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疫苗在预防细菌抗药性中的作用。

全球范围内，细菌病原体引起的抗菌素耐药性（AMR）以及相关的发病率和死亡率一直在上升，达到令人震惊的水平。世界卫生组织（WHO）呼吁针对AMR采取全球行动，并得到世界各国政府，卫生部和卫生机构的支持。干AMR的许多潜在解决方案正在讨论和实施。这些措施包括增加抗菌素管理，在研发方面进行投资以设计新型的抗生素，以及减少在牲畜饲养中使用抗生素。但是，尽管在减少疾病和AMR方面的有效性已有充分的文献证明，但在过去的这些讨论中，人们一直未充分认识到作为减少AMR的工具的疫苗。这篇评论文章旨在强调疫苗作为全球对抗AMR的另一种方式的价值，使用精选示例。它还将提供有关如何在此工作中更有效地使用疫苗的观点。