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Anti-biofouling and antibacterial surfaces via a multicomponent coating deposited from an up-scalable atmospheric-pressure plasma-assisted CVD process†
Journal of Materials Chemistry B ( IF 7 ) Pub Date : 2018-01-09 00:00:00 , DOI: 10.1039/c7tb02473h
Maryline Moreno-Couranjou 1, 2, 3 , Rodolphe Mauchauffé 1, 2, 3 , Sébastien Bonot 1, 2, 3 , Christophe Detrembleur 4, 5, 6, 7, 8 , Patrick Choquet 1, 2, 3
Affiliation  

Prevention of bacterial adhesion and biofilm formation on the surfaces of materials is a topic of major medical and societal importance. In this study, an up-scalable atmospheric-pressure plasma assisted deposition method is introduced to produce a multicomponent coating towards the elaboration of antibacterial and anti-biofilm surfaces. Interestingly, from a single catechol-based monomer, high deposition rates of highly chemically reactive functional thin films bearing catechol as well as quinone groups are achieved. The catechol-bearing thin film allows the in situ silver nanoparticle formation, assessed by scanning electron microscopy and EDX, whilst the enriched-quinone thin film is exploited for immobilizing dispersine B, an enzyme. In vitro functional assays demonstrated the dual antibacterial and anti-biofouling resistance properties of the coatings due to the antibacterial effect of silver and the fouling resistance of grafted dispersine B, respectively. Surfaces coated only with silver provide an antibacterial effect but fail to inhibit bacterial attachment, highlighting the usefulness of such dual-action surfaces. The approach presented here provides a simple and effective chemical pathway to construct powerful antibacterial surfaces for various industrial applications.

中文翻译:

通过可升级的大气压等离子辅助CVD工艺沉积的多组分涂层实现 防污垢和抗菌表面

预防材料表面上的细菌粘附和生物膜形成是医学和社会上重要的话题。在这项研究中,引入了一种可升级的大气压等离子体辅助沉积方法,以生产出多组分的涂层,以形成抗菌和抗生物膜的表面。有趣的是,从单一的基于邻苯二酚的单体可以实现具有邻苯二酚和醌基团的高化学反应性功能薄膜的高沉积速率。含儿茶酚的薄膜允许原位形成银纳米粒子,通过扫描电子显微镜和EDX进行评估,而富醌薄膜则用于固定酶分散素B。体外功能测定证明了分别由于银的抗菌作用和接枝的分散素B的抗结垢性,涂层具有双重抗菌和抗生物结垢特性。仅涂有银的表面具有抗菌作用,但不能抑制细菌附着,突出了这种双重作用表面的有用性。本文介绍的方法提供了一种简单有效的化学途径,可为各种工业应用构建强大的抗菌表面。
更新日期:2018-01-09
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