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Specific labeling of mitochondria of Chlamydomonas with cationic helicene fluorophores†
Organic & Biomolecular Chemistry ( IF 3.2 ) Pub Date : 2018-01-09 00:00:00 , DOI: 10.1039/c7ob02906c
Christoph Bauer 1, 2, 3, 4 , Romain Duwald 2, 4, 5, 6 , Geraldine Maria Labrador 2, 4, 5, 6 , Simon Pascal 2, 4, 5, 6 , Pau Moneva Lorente 2, 4, 5, 6 , Johann Bosson 2, 4, 5, 6 , Jérôme Lacour 2, 4, 5, 6 , Jean-David Rochaix 2, 3, 4, 7
Affiliation  

Twelve cationic helicenes and one triangulene were tested for the specific labeling of mitochondria from algal cells. Octyl ester derivative 5 readily penetrates algal cells and gives rise to clear fluorescence patterns when it is used at concentrations in the μM range. Under these conditions, cell structures are well preserved and cell survival is not compromised. Cationic helicene compounds such as 5 provide new useful tools for examining the mitochondrial network and its dynamics including fission and fusion events.

中文翻译:

阳离子螺旋烯荧光团 对衣藻线粒体的特异性标记

测试了十二个阳离子螺旋烯和一个三茂铁对藻类细胞线粒体的特异性标记。辛酸酯衍生物5在μM范围内使用时,很容易穿透藻类细胞并产生清晰的荧光图案。在这些条件下,细胞结构得到了很好的保存,细胞的生存也没有受到损害。诸如5之类的阳离子螺旋烯化合物为检测线粒体网络及其动力学(包括裂变和聚变事件)提供了新的有用工具。
更新日期:2018-01-09
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