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The Secret Life of Exosomes
Journal of the American College of Cardiology ( IF 24.0 ) Pub Date : 2018-01-01 , DOI: 10.1016/j.jacc.2017.11.013
Eduardo Marbán

Mechanistic exploration has pinpointed nanosized extracellular vesicles, known as exosomes, as key mediators of the benefits of cell therapy. Exosomes appear to recapitulate the benefits of cells and more. As durable azoic entities, exosomes have numerous practical and conceptual advantages over cells. Will cells end up just being used to manufacture exosomes, or will they find lasting value as primary therapeutic agents? Here, a venerable natural process-the generation of honey-serves as an instructive parable. Flowers make nectar, which bees collect and process into honey. Cells make conditioned medium, which laboratory workers collect and process into exosomes. Unlike flowers, honey is durable, compact, and nutritious, but these facts do not negate the value of flowers themselves. The parallels suggest new ways of thinking about next-generation therapeutics.

中文翻译:

外泌体的秘密生活

机制探索已确定纳米尺寸的细胞外囊泡(称为外泌体)是细胞治疗益处的关键介质。外泌体似乎概括了细胞等的好处。作为持久的偶氮实体,外泌体比细胞具有许多实际和概念上的优势。细胞最终会被用来制造外泌体,还是它们会发现作为主要治疗剂的持久价值?在这里,一个古老的自然过程——蜂蜜的产生——是一个有启发性的寓言。花产生花蜜,蜜蜂收集花蜜并加工成蜂蜜。细胞制造条件培养基,实验室工作人员将其收集并加工成外泌体。与鲜花不同,蜂蜜耐用、紧致且营养丰富,但这些事实并没有否定鲜花本身的价值。
更新日期:2018-01-01
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