Cholecalciferol (D₃) and retinyl palmitate (RP) are the two main fat-soluble vitamins found in foods from animal origin. It is assumed that they are solubilized in mixed micelles prior to their uptake by intestinal cells, but only scarce data are available on the relative efficiency of this process and the molecular interactions that govern it. The extent of solubilization of D₃ and RP in micelles composed of lipids and sodium taurocholate (NaTC) was determined. Then, the molecular interactions between components were analyzed by surface tension and surface pressure measurements. The mixture of lipids and NaTC allowed formation of micelles with higher molecular order, and at lower concentrations than pure NaTC molecules. D₃ solubilization in the aqueous phase rich in mixed micelles was several times higher than that of RP. This was explained by interactions between NaTC or lipids and D₃ thermodynamically more favorable than with RP, and by D₃ self-association.

胆钙化固醇（D ₃）和棕榈酸视黄酯（RP）是动物源性食品中发现的两种主要的脂溶性维生素。假定它们在被肠道细胞吸收之前已经溶解在混合的胶束中，但是关于该过程的相对效率以及控制该过程的分子相互作用只有很少的数据可用。确定由脂质和牛磺胆酸钠（NaTC）组成的胶束中D ₃和RP的溶解程度。然后，通过表面张力和表面压力测量来分析组分之间的分子相互作用。与纯NaTC分子相比，脂质和NaTC的混合物可形成更高分子序且浓度更低的胶束。d ₃在富含混合胶束的水相中的溶解度比RP高出几倍。NaTC或脂质与D _3在热力学上比与RP相互作用更有利，并且D ₃自缔合可以解释这一点。