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Front Cover: Mitochondria‐Targeting Polyamine–Protoporphyrin Conjugates for Photodynamic Therapy (ChemMedChem 1/2018)
ChemMedChem ( IF 3.4 ) Pub Date : 2018-01-08 , DOI: 10.1002/cmdc.201700806
Fargol Taba 1 , Akira Onoda 1 , Urara Hasegawa 1, 2 , Toshiaki Enoki 3 , Yousuke Ooyama 3 , Joji Ohshita 3 , Takashi Hayashi 1
Affiliation  

The Front Cover shows photodynamic therapy (PDT) agents targeting and attacking mitochondria through their two polyamine linkers. Protoporphyrin IX derivatives tethering four‐ or eight‐amine moieties with rigid spacers have great potential for use in mitochondrial targeting, which was clearly visualized by confocal imaging studies. With light activation, these PDT agents can damage the cells. The molecules exhibit excellent singlet oxygen quantum yields and show strong in vitro PDT efficacy after 660 nm laser irradiation in HT29 colorectal cancer and HEP3B liver cancer cell lines. This work demonstrates that polyamine moieties on photosensitizers can enhance PDT efficacy by targeting mitochondria. More information can be found in the Communication by Fargol Taba, Akira Onoda, Takashi Hayashi et al. on page 15 in Issue 1, 2018 (DOI: 10.1002/cmdc.201700467).
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中文翻译:

封面:线粒体靶向多胺-原卟啉结合用于光动力疗法(ChemMedChem 1/2018)

封面显示了通过其两个多胺接头靶向并攻击线粒体的光动力疗法(PDT)剂。将四胺或八胺部分与刚性间隔基连接在一起的原卟啉IX衍生物在线粒体靶向中具有巨大的潜力,共聚焦成像研究清楚地显示了这一点。通过光激活,这些PDT剂会损坏细胞。该分子在HT29大肠癌和HEP3B肝癌细胞系中表现出出色的单线态氧量子产率,并在660 nm激光照射后显示出强大的体外PDT功效。这项工作表明光敏剂上的多胺部分可以通过靶向线粒体来增强PDT的功效。更多信息,请参见Fargol Taba的通讯,Onoda的Akira,Takashi Hayashi等的信息。上2018年第1期,第15页(DOI:10.1002 / cmdc.201700467)。
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更新日期:2018-01-08
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