New organometallic complexes [M(dppe)(R)₂] {where M = Pt or Pd, dppe = 1,2-bis(diphenylphosphano)ethane, and R = C₆F₄H-x (x = 6,5,4), C₆F₃H₂-3,5, C₆F₃H₂-5,6, C₆F₃H₂-3,6, C₆F₄(OMe)-4, and C₆F₄(cyclo-C₅H₁₀N)-4, the numbers x refer to the positions of the protons in the polyfluoroaryl ligands} were synthesised either through transmetalation from the dichlorido complexes [M(dppe)Cl₂] or through ligand exchange using [M(diene)Cl₂] precursor complexes with diene = 1,5-cyclooctadiene (cod) or 1,5-hexadiene (hex). Alternatively, [M(dppX)Cl(R)] complexes with dppX = dppm (1,1-bis(diphenylphosphano)methane), dppe, dppp (1,3-bis(diphenylphosphano)propane), and dppb (1,4-bis(diphenylphosphano)butane) were prepared in decarboxylation reactions from thallium(I) carboxylates Tl(O₂CR). The different preparative methods were compared in terms of yield and purity. Structural and spectroscopic data are reported for the new dppX- and diene-M(R)₂ complexes. Antiproliferative activity was investigated for these new complexes against the HT-29 (colon carcinoma) and MCF-7 (breast adenocarcinoma) cell lines, and the active compounds of this first series together with organometallic dppX or hex Pt^II or Pd^II complexes were then included in cell tests using L1210 (leukaemia cells) and the cisplatin-resistant L1210/DDP cell line. Remarkably, promising antiproliferative results were found for a few Pt^II and Pd^II complexes, while structurally closely related compounds were essentially nontoxic.

中文翻译：

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一系列新型铂和钯二膦配合物的合成和抗增殖活性†

新的有机金属配合物[M（dppe）（R）₂ ] {其中M = Pt或Pd，dppe = 1,2-双（二苯基膦基）乙烷，R = C ₆ F ₄ H- x（x = 6,5， 4），C ₆ F ₃ H ₂ -3,5，C ₆ F ₃ H ₂ -5,6，C ₆ F ₃ H ₂ -3,6，C ₆ F ₄（OMe）-4和C ₆ F ₄（环-C ₅ H ₁₀ N）-4，数字x指质子在多氟芳基配体中的位置}是通过从二氯键合物[M（dppe）Cl ₂ ]进行金属转移或通过使用[M（diene）Cl ₂ ]前体配合物与二烯= 1,5进行配体交换而合成的-环辛二烯（cod）或1,5-己二烯（hex）。或者，[M（dppX）Cl（R）]与dppX = dppm（1,1-双（二苯基膦基）甲烷），dppe，dppp（1,3-双（二苯基膦基）丙烷）和dppb（1,4在脱羧反应中由th（I）的羧酸盐Tl（O ₂ CR）制备了-双（二苯基膦基）丁烷。比较了不同制备方法的收率和纯度。报告了新的dppX-和diene-M（R）_2的结构和光谱数据复合体。研究了这些新复合物对HT-29（结肠癌）和MCF-7（乳腺癌）细胞系的抗增殖活性，然后将第一系列的活性化合物与有机金属dppX或hex Pt ^II或Pd ^II复合物一起进行了研究。包括在使用L1210（白血病细胞）和耐顺铂L1210 / DDP细胞系的细胞测试中。值得注意的是，发现了一些Pt ^II和Pd ^II复合物有希望的抗增殖结果，而结构上密切相关的化合物基本上是无毒的。