Three new chiral metal coordination complexes, namely, [Cu(FZ)₂(CH₃COO)₂(H₂O)]·2H₂O (1), [Cu(FZ)₂(NO₃)₂] (2), and [Cu₂(FZ)₂ (H₂O)₈](SO₄)₂·4H₂O (3) [FZ = (2R,3S)-2-(2,4-difluorophenyl)-3-(5-fluoro-4-pyrimidiny)-1-(1H-1,2,4-triazol-1-yl)-2-butanol) (Voriconazole)] have been obtained by the reaction of Cu(II) salts and the free ligand FZ at room temperature. Complexes 1–3 were structurally characterized by X-ray single-crystal diffraction, IR, UV–vis, powder X-ray diffraction (PXRD), and thermogravimetric analysis (TGA). Complex 1 crystallizes in the chiral space group C₂, which exhibits a mono-nuclear structure. Both complexes 2 and 3 display a one-dimensional (1D) tape structure, which crystallize in chiral space group P2₁2₁2 and P2₁2₁2₁, respectively. Among these complexes, there exist a variety of hydrogen bonds and stacking interactions, through which a three-dimensional supramolecular architecture will be generated. Compared with the standard (Voriconazole), these Cu-based complexes show the more potent inhibiting efficiency against the species of Candida and Aspergillus. Moreover, among these complexes, complex 1 shows the most excellent efficiency.

三种新的手性金属配位化合物，即[Cu（FZ）₂（CH ₃ COO）₂（H ₂ O）]·2H ₂ O（1），[Cu（FZ）₂（NO ₃）₂ ]（2）和[Cu ₂（FZ）₂（H ₂ O）₈ ]（SO ₄）₂ ·4H ₂ O（3）[ FZ =（2 R，3 S）-2-（2,4-二氟苯基）-3 -（5-氟-4-嘧啶）-1-（1通过在室温下使Cu（II）盐与游离配体FZ反应获得[ H -1,2,4-三唑-1-基）-2-丁醇）（伏立康唑）。配合物1 - 3分别结构特征在于X-射线单晶衍射，IR，UV-VIS，粉末X射线衍射（PXRD），和热重分析（TGA）。络合物1在手性空间群C _2中结晶，该手性空间群显示出单核结构。配合物2和3均显示一维（1D）带状结构，该结构在手性空间群P 2 ₁ 2 ₁ 2和P 2中结晶₁ 2 ₁ 2 ₁。在这些配合物中，存在各种氢键和堆积相互作用，通过它们将产生三维超分子结构。与标准品（伏立康唑）相比，这些基于铜的配合物显示出对念珠菌和曲霉菌更有效的抑制作用。此外，在这些配合物中，配合物1显示出最优异的效率。