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Developing Bis(imino)acenaphthene-Supported N-Heterocyclic Carbene Palladium Precatalysts for Direct Arylation of Azoles
Organometallics ( IF 2.8 ) Pub Date : 2018-01-05 00:00:00 , DOI: 10.1021/acs.organomet.7b00784
Li-Qun Hu 1 , Rong-Li Deng 1 , Yan-Fen Li 1 , Cui-Jin Zeng 1 , Dong-Sheng Shen 1 , Feng-Shou Liu 1
Affiliation  

On the basis of the strategy of developing highly efficient protocol for Pd-catalyzed cross-coupling reactions, a series of bulky bis(imino)acenaphthene (BIAN)-supported Pd-PEPPSI complexes were synthesized, characterized, and applied in direct arylation of azoles. The effect of backbone and N-moieties on NHCs was evaluated, and the reaction conditions were optimized. It was found that the bulky Pd-PEPPSI complexes could be successfully employed in cross-coupling of (hetero)aryl bromides with azoles at a low palladium loading of 0.5–0.05 mol % under aerobic conditions, demonstrating the ease of manipulation without glovebox and handling of solvents.

中文翻译:

研发双(亚氨基)ph啶负载的N-杂环碳钯钯预催化剂,用于芳族化合物的直接芳基化

在开发高效的Pd催化交叉偶联反应方案的策略的基础上,合成,表征了一系列大体积的双(亚氨基)ena(BIAN)负载的Pd-PEPPSI复合物,并将其用于吡咯的直接芳基化。评估了主链和N-部分对NHC的影响,并优化了反应条件。研究发现,大体积的Pd-PEPPSI复合物可以在有氧条件下以0.5-0.05 mol%的低钯负载量成功地用于(杂)芳基溴化物与吡咯类的交叉偶联,这表明无需手套箱即可轻松操作溶剂。
更新日期:2018-01-06
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