An iodine-promoted three-component reaction for the construction of spirooxindoles has been developed through the green reaction system of catalytic amount of molecular iodine as an alternative catalyst for Lewis acids. Various substituted isatins were able to react with different cyclic 1,3-dicarbonyls and 4-hydroxyl coumarins through this reaction strategy, which shows good functional group tolerance and efficiency.

中文翻译：

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碘促进的三组分反应合成螺毒素

通过催化量的分子碘作为路易斯酸的替代催化剂的绿色反应体系，已经开发出碘促进的三组分反应来构建螺硫醇。通过这种反应策略，各种取代的isatin能够与不同的环状1,3-二羰基化合物和4-羟基香豆素反应，显示出良好的官能团耐受性和效率。