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Combination ART: are two drugs as good as three?
The Lancet ( IF 168.9 ) Pub Date : 2018-01-05 , DOI: 10.1016/s0140-6736(18)30008-4
Mark A Boyd , David A Cooper

First page of articleThe first 10 years of the development of antiretroviral therapy (ART) were characterised by a series of studies that led to the conclusion that triple therapy was the minimum required to induce and maintain full suppression of HIV replication. Early reports of using monotherapy with a nucleoside reverse transcriptase inhibitor (NRTI) had shown only transient decreases in p24 antigen and arrest of HIV disease progression.1 Studies of dual NRTI therapy showed more robust responses, but again these responses were temporary and unsustained in most individuals in the studies.

中文翻译:

组合ART:两种药物和三种药物一样好吗?

文章首页抗逆转录病毒疗法(ART)发展的最初十年以一系列研究为特征,得出的结论是,三联疗法是诱导和维持HIV复制完全抑制的最低要求。早期使用核苷逆转录酶抑制剂(NRTI)进行单药治疗的报道表明,p24抗原仅短暂减少,而HIV疾病进展却停滞不前。[1 ]双重NRTI疗法的研究显示出更强的反应,但在大多数研究中,这些反应都是暂时的且不可持续。
更新日期:2018-03-02
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