In this issue of Blood, El Ashkar et al1 reveal that the lens epithelium-derived growth factor (LEDGF) protein is a key therapeutic target by showing that it is essential for leukemia, but not normal hematopoiesis. Such context-dependent information is important for the development of new targeted therapies.

中文翻译：

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LEDGF：白血病特异性靶标

在本期血液中，El Ashkar 等人 1 揭示了晶状体上皮衍生生长因子 (LEDGF) 蛋白是一个关键的治疗靶点，因为它表明它对白血病是必不可少的，但对正常的造血不重要。这种依赖上下文的信息对于开发新的靶向疗法很重要。