Each year millions of children in low- and middle-income countries (LMIC) fail to reach their developmental potential due to factors including poverty, malnutrition, poor stimulation and HIV. Although vertically-acquired HIV can now be prevented, little is known about the impact of HIV exposure in fetal and early life on the development of the many HIV-negative children. The Siyakhula Cohort was established within the Canadian Grand Challenges ‘Saving Brains’ initiative, to support re-enrolment of strategic cohorts in LMIC. This unique cohort in rural South Africa includes 1536 HIV-negative children born to HIV-infected (HIV-exposed) and HIV-uninfected (unexposed) mothers, enrolled from the Africa Health Research Institute (AHRI)–formerly the Africa Centre for Population Health (Africa Centre). The cohort includes data on HIV exposure in fetal and early life, and other early life factors (including breastfeeding) known to impact on later health outcomes. At birth, all children benefited from the early Prevention of Mother-to-Child-Transmission of HIV services in the district, and a subgroup were part of an additional early life breastfeeding intervention, the Vertical Transmission Study (VTS). This cohort pre-dated antiretroviral treatment (ART) roll-out, allowing for examination of outcomes associated with HIV exposure without ART exposure in utero and during breastfeeding. Current assessments at ages 7–11 years collected data on growth, health, cognition (including executive function), education and emotional-behavioural outcomes at primary school age.

中文翻译：

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队列资料：Siyakhula队列，南非农村

每年由于贫穷，营养不良，不良刺激和艾滋病毒等因素，中低收入国家（LMIC）的数百万儿童无法发挥其发展潜力。尽管现在可以预防垂直获得的艾滋病毒，但对于胎儿和早期生活中的艾滋病毒暴露对许多艾滋病毒阴性儿童的成长的影响知之甚少。Siyakhula群组是在加拿大大挑战“拯救大脑”倡议下设立的，旨在支持LMIC战略群组的重新注册。南非农村地区的这一独特人群包括1536名由感染HIV（暴露于HIV）的母亲和未感染HIV（未暴露）的母亲所生的HIV阴性孩子，这些孩子是从非洲健康研究所（AHRI）（以前是非洲人口健康中心）招募的（非洲中心）。该队列包括有关胎儿和早期感染艾滋病毒的数据以及已知会影响后期健康结果的其他早期生命因素（包括母乳喂养）。出生时，所有儿童都从该地区的早期预防母婴传播艾滋病毒服务中受益，其中一个分组是额外的早期生命母乳喂养干预措施，即垂直传播研究（VTS）。该研究组在抗逆转录病毒治疗（ART）之前推出，可在不进行ART暴露的情况下检查与HIV暴露相关的结局 和一个亚组是额外的早期母乳喂养干预措施，即垂直传播研究（VTS）的一部分。该研究组在抗逆转录病毒治疗（ART）之前推出，可在不进行ART暴露的情况下检查与HIV暴露相关的结局 和一个亚组是额外的早期母乳喂养干预措施，即垂直传播研究（VTS）的一部分。该研究组提前进行了抗逆转录病毒治疗（ART），可在不进行ART暴露的情况下检查与HIV暴露相关的结局在子宫内和母乳喂养期间。目前对7-11岁年龄段的评估收集了有关小学年龄阶段的生长，健康，认知（包括执行功能），教育和情绪行为结果的数据。