### Excess lipids meddle with mitochondrial function in the heart, report Tsushima et al. Obesity and diabetes are 2 major risk factors for heart disease and can lead to myocardial lipotoxicity—cardiac dysfunction caused by excessive fatty acid accumulation. At a pathological level, lipotoxicity has been associated with mitochondrial dysfunction, but exactly how excess lipids affect mitochondria is unclear. To find out, Tsushima and colleagues studied mice that were genetically engineered to accumulate excess fatty acids specifically in their cardiac myocytes. These animals ultimately developed heart failure, but not until they are ≈4 months old, giving the team the opportunity to study pathological progression of lipotoxicity. In early weeks of life, excess lipids were associated with an increase in mitochondrial activity. Prolonged excess, however, …

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在这个问题上

津岛等人报告说，过多的脂质混入了心脏的线粒体功能。肥胖和糖尿病是心脏病的两个主要危险因素，可导致心肌脂中毒-脂肪酸过多积聚导致的心脏功能障碍。在病理学水平上，脂毒性与线粒体功能障碍有关，但尚不清楚脂质过多如何影响线粒体。为了找到答案，Tsushima及其同事研究了经过基因工程改造的小鼠，这些小鼠专门在其心肌细胞中蓄积了多余的脂肪酸。这些动物最终会出现心力衰竭，但直到大约4个月大时才出现，从而为研究小组提供了研究脂毒性病理进展的机会。在生命的最初几周，过多的脂质与线粒体活性的增加有关。长期过量