4-Methyl-1-(3-sulfopropyl)pyridinium hydrogen sulfate ([MSPP][HSO₄]) as a new acidic ionic liquid was prepared in a quick and easy process, and characterized by some techniques such as ¹H NMR, ¹³C NMR and FT-IR analysis. Then, [MSPP][HSO₄] was immobilized on silica nanoparticles by impregnation method to afforded heterogeneous acidic ionic liquid ([MSPP]HSO₄@nSiO₂) and characterized by elemental analysis (CHNS), FT-IR, and SEM. The worthiness of [MSPP]HSO₄@nSiO₂ has been investigated for the synthesis of various substituted phthalazine-ones as well as selective synthesis of mono- and bis-phthalazine-ones as imperative biologically active compounds. The reaction has been carried out under solvent-free conditions, simple work-up procedure and the products were obtained in excellent to good yields. Moreover, the catalyst was reused five times without decay in catalytic activity performance.

通过快速简便的方法制备了作为新型酸性离子液体的4-甲基-1-（3-磺丙基）吡啶鎓硫酸氢盐（[MSPP] [HSO ₄ ]），并通过一些技术进行了表征，例如¹ H NMR，¹³ 1 H NMR和FT-IR分析。然后，通过浸渍法将[MSPP] [HSO ₄ ]固定在二氧化硅纳米颗粒上，得到多相酸性离子液体（[MSPP] HSO ₄ @nSiO ₂），并通过元素分析（CHNS），FT-IR和SEM进行表征。[MSPP] HSO ₄ @nSiO _2的价值已研究了用于合成各种取代的酞嗪酮以及选择性合成作为命令性生物活性化合物的单-和双-酞嗪酮的方法。该反应已在无溶剂条件下进行，后处理步骤简单，并以优异的收率获得了产物。而且，该催化剂被重复使用了五次而没有降低催化活性。