Insecticide nicotine hydrochloride (NCT) was formulated as nanoparticles composed of chitosan (CS) and sodium tripolyphosphate (TPP) to undermine its adverse impacts on human health and reinforce its physicochemical stability. The study investigated the preparation and characterization of chitosan/tripolyphosphate nanoparticles (CS/TPP NPs) with good encapsulation efficiency (55%), uniform morphology, and physicochemical stability (45 days) through dynamic light scattering (DLS), transmission electron microscopy (TEM), and small-angle X-ray scattering (SAXS) measurements. A bioassay against Musca domestica NCT CS/TPP NPs exhibited good bioactivity and thermal stability. The effect of the monovalent salt (NaCl) on manipulating the formation and size distribution of ionically cross-linked nanoparticles was demonstrated as well. The formulation of NCT CS/TPP NPs could be a utility candidate in public health and agriculture.

中文翻译：

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通过封装在壳聚糖/三聚磷酸酯纳米粒子中的环保配方的杀虫剂烟碱盐酸盐的制备。

将杀虫剂烟碱盐酸盐（NCT）配制成由壳聚糖（CS）和三聚磷酸钠（TPP）组成的纳米颗粒，以破坏其对人体健康的不利影响并增强其理化稳定性。该研究通过动态光散射（DLS），透射电子显微镜（TEM）研究了壳聚糖/三聚磷酸盐纳米粒子（CS / TPP NPs）的制备和表征，该纳米粒子具有良好的包封率（55％），均匀的形态和理化稳定性（45天）。 ）和小角度X射线散射（SAXS）测量。对家蝇的生物测定NCT CS / TPP NPs具有良好的生物活性和热稳定性。还证明了单价盐（NaCl）对操纵离子交联纳米粒子的形成和尺寸分布的影响。NCT CS / TPP NP的制定可能是公共卫生和农业中的实用候选。