Although it has historically been studied in the context of cancer, recent literature has highlighted the importance of the highly conserved serine/threonine kinase casein kinase II (CK2) in inflammatory disorders. Most strikingly, CK2 is a major regulator of the Th17–Treg axis relevant to many T cell-driven autoimmune disorders including multiple sclerosis (MS).

中文翻译：

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蛋白激酶 CK2：新兴的免疫调节剂

尽管历史上一直在癌症背景下进行研究，但最近的文献强调了高度保守的丝氨酸/苏氨酸激酶酪蛋白激酶 II (CK2) 在炎症性疾病中的重要性。最引人注目的是，CK2 是 Th17-Treg 轴的主要调节因子，与许多 T 细胞驱动的自身免疫性疾病（包括多发性硬化症 (MS)）相关。