We previously described the gelation mechanism of calcium polyphosphate (CPP) in the presence of water. In this study, we developed novel and injectable poly-dicalcium phosphate dihydrate (P-DCPD) forming cement by the reaction of acidic CPP gel with alkali tetracalcium phosphate (TTCP). The setting reaction mechanism of P-DCPD is due to the intermolecular interaction between CPP gel and TTCP that was supported by XRD, AFM, Raman spectra analysis and SEM. The setting mechanism of P-DCPD is completely different from the classical calcium phosphate cement (CPC) that achieves crystallization by monophosphates reaction. P-DCPD represents a new type of poly-CPCs with significant advantages, including strong mechanical strength, excellent cohesion and easy of handling. More extensive experiments are currently underway to further evaluate the performance of P-DCPD cements, including biocompatibility, degradation behavior and bone defect hearing efficacy, among others.

我们先前描述了在水的存在下聚磷酸钙（CPP）的胶凝机理。在这项研究中，我们通过酸性CPP凝胶与碱性磷酸四钙（TTCP）的反应开发了新型可注射的聚磷酸二钙二水合物（P-DCPD）形成水泥。P-DCPD的固化反应机理是由于XRD，AFM，拉曼光谱分析和SEM支持CPP凝胶和TTCP之间的分子间相互作用。P-DCPD的凝结机理与通过单磷酸盐反应实现结晶的经典磷酸钙水泥（CPC）完全不同。P-DCPD代表一种新型的Poly-CPC，具有显着的优势，包括强大的机械强度，出色的内聚力和易于处理的特性。