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Impact of endocrine disrupting compounds in sewage impacted coastal area on seabream
Ecotoxicology and Environmental Safety ( IF 6.8 ) Pub Date : 2018-01-04 , DOI: 10.1016/j.ecoenv.2017.12.035
Noura Al-Jandal , Talat Saeed , Ismail Azad , Sherain Al-Subiai , Waleed Al-Zekri , Sumaiah Hussain , Enas Al-Hasan

The pollution of coastal regions worldwide has been of a great concern due to the presence of endocrine disrupting chemicals (EDCs). These chemicals find their way to the marine environment via the sewage treatment plants (STPs). Hence, this study was designed to investigate the status and sources of EDCs and their effect on fish in Kuwait's coastal areas, from the chemical and biological perspectives. The assessment of three STPs indicated the presence of significant levels of phthalates (19 and 31 µg/l), alkylphenols (85 and 159 ng/l), and estrogens (30 and 368 ng/l) in both inflow and outflow samples. The analysis of samples from field exposure sites revealed significant levels of EDCs in seawater (phthalates: 2.1–4.6 µg/l; alkylphenols: 1.2–16.4 ng/l; estrogens: 0–36.2 ng/l) and sediment (phthalates: 2.1–15.7 mg/kg dry wt; alkyphenols: 2.5–15.1 µg/kg dry wt.; estrogens: 4.1–214.2 µg/kg dry wt.) samples. The biological perspective investigated through the exposure of fish to sewage outlets at five sites. The hepatosomatic index (HSI) revealed a higher level in winter samples 0.48–0.79%) in comparison to summer samples 1–1.5%). Histological observation of hepatic tissue of fish exposed during winter months in all sites, showed much less necrotic changes and hepatic vacuolation in the hepatic tissue of summer exposed fish. Imunnohistochemistry evidences revealed a significant level of positive signals and Vtg localization in the hepatic tissue as the results support the histopathological alterations observed. Results of enzyme-linked immunosorbent assay (ELISA) showed no significant difference between the plasma protein content of winter and summer samples. Overall, the study suggest that there is possible local source or a chronic input of untreated and/or partially treated water due to the significant levels of phthalates, alkyphenols, and estrogens detected in the Kuwait Bay. These levels were enough to initiate alteration in the hepatic tissue of fish exposed to the sewage outlets in Kuwait for two weeks.



中文翻译:

受污水影响的沿海地区内分泌干扰化合物对鲷鱼的影响

由于存在内分泌干扰化学物质(EDC),全球沿海地区的污染一直备受关注。这些化学物质通过污水处理厂(STP)进入海洋环境。因此,本研究旨在从化学和生物学的角度调查EDC的现状和来源以及它们对科威特沿海地区鱼类的影响。对三种STP的评估表明,流入和流出样品中邻苯二甲酸盐(19和31 µg / l),烷基酚(85和159 ng / l)和雌激素(30和368 ng / l)的含量都很高。对现场暴露场所样品的分析表明,海水和沉积物(邻苯二甲酸盐:2.1–4.2)中的EDC含量很高(邻苯二甲酸盐:2.1–4.6 µg / l;烷基酚:1.2–16.4 ng / l;雌激素:0–36.2 ng / l)。 15.7 mg / kg干重;烷基酚:2。5–15.1 µg / kg干重;雌激素:4.1–214.2 µg / kg干重。通过将鱼暴露于五个地点的排污口进行生物学角度的调查。肝样本(HSI)在冬季样本中的含量较高,为0.48–0.79%,而夏季样本中的含量为1–1.5%。在所有部位冬季暴露的鱼肝组织的组织学观察显示,夏季暴露的鱼肝组织中的坏死变化和肝空泡少得多。免疫组织化学证据显示,在肝组织中有明显水平的阳性信号和Vtg定位,因为结果支持观察到的组织病理学改变。酶联免疫吸附试验(ELISA)的结果表明,冬季和夏季样品的血浆蛋白含量之间无显着差异。全面的,该研究表明,由于在科威特湾中检测到大量邻苯二甲酸盐,烷基酚和雌激素,可能存在未经处理和/或部分处理的水的局部来源或长期输入。这些水平足以引发暴露于科威特排污口达两周的鱼肝组织的改变。

更新日期:2018-01-04
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