Beta cell replacement strategies hold promise for permanently treating type 1 diabetes. In Cell Stem Cell, Xiao et al. (2018) restore pancreatic beta cell mass and normalize blood glucose in diabetic mice by reprogramming pancreatic alpha to beta cells using Pdx1- and Mafa-expressing adeno-associated virus infused into the pancreatic duct.

中文翻译：

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从Alpha到Beta细胞的重新编程：迈向糖尿病的新疗法。

Beta细胞替代策略有望永久治疗1型糖尿病。在Cell Stem Cell中，Xiao等人。（2018）通过使用注入胰管的Pdx1和Mafa表达的腺相关病毒将胰腺α重编程为β细胞，从而恢复糖尿病小鼠的胰腺β细胞质量并使血糖正常化。