A Co(III)‐catalyzed C−H activation reaction for ortho‐alkenylation of benzamides (aryl/heteroaryl) and C2‐alkenylation of indole derivatives have been developed using alkynyl carboxylic acid as an alkene source. A high regioselectivity has been achieved in the formation of disubstituted alkenes, and the possible cyclic products were not observed. This efficient alkenylation shows a broad range of substrate scope with a good functional group tolerance. The application of the methodology has been showcased by transforming an alkenylated amide to a 3‐hydroxy isoindolinone derivative.

中文翻译：

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钴（III）催化的CH活化：仲酰胺定向脱羧的炔基羧酸的脱羧官能团，其中酰胺NH-基团保持不活泼

将Co（III）催化的C-H活化反应为邻苯甲酰胺（芳基/杂芳基）和吲哚衍生物的C 2烯基的-alkenylation使用炔基羧酸作为烯烃源已被开发。在二取代烯烃的形成中已经实现了高区域选择性，并且未观察到可能的环状产物。这种有效的烯基化显示了广泛的底物范围，具有良好的官能团耐受性。通过将烯基化酰胺转化为3-羟基异吲哚满酮衍生物，展示了该方法的应用。