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Brevetoxin (PbTx-2) influences the redox status and NPQ of Karenia brevis by way of thioredoxin reductase
Harmful Algae ( IF 6.6 ) Pub Date : 2018-01-03 , DOI: 10.1016/j.hal.2017.11.004
Wei Chen , Ricardo Colon , J.William Louda , Freddy Rodriguez del Rey , Michaella Durham , Kathleen S. Rein

The Florida red tide dinoflagellate, Karenia brevis, is the major harmful algal bloom dinoflagellate of the Gulf of Mexico and plays a destructive role in the region. Blooms of K. brevis can produce brevetoxins: ladder-shaped polyether (LSP) compounds, which can lead to adverse human health effects, such as reduced respiratory function through inhalation exposure, or neurotoxic shellfish poisoning through consumption of contaminated shellfish. The endogenous role of the brevetoxins remains uncertain. Recent work has shown that some forms of NADPH dependent thioredoxin reductase (NTR) are inhibited by brevetoxin-2 (PbTx-2). The study presented herein reveals that high toxin and low toxin K. brevis, which have a ten-fold difference in toxin content, also show a significant difference in their ability, not only to produce brevetoxin, but also in their cellular redox status and distribution of xanthophyll cycle pigments. These differences are likely due to the inhibition of NTR by brevetoxin. The work could shed light on the physiological role that brevetoxin fills for K. brevis.



中文翻译:

短毒素(PbTx-2)通过硫氧还蛋白还原酶影响短毛克雷耶氏菌的氧化还原状态和NPQ

佛罗里达州赤潮鞭毛藻,Karenia brevis,是墨西哥湾的主要有害藻华鞭毛藻,在该地区起着破坏性作用。K.brevis的花朵会产生短毒素:梯形聚醚(LSP)化合物,可能导致不良的人类健康影响,例如因吸入暴露而导致呼吸功能下降,或由于食用受污染的贝类而引起神经毒性贝类中毒。短毒素的内源性作用仍然不确定。最近的工作表明,某些形式的NADPH依赖性硫氧还蛋白还原酶(NTR)被brevetoxin-2(PbTx-2)抑制。本文介绍的研究表明,高毒素和低毒素短杆菌K. brevis在毒素含量上有十倍的差异,不仅在产生短毒素方面,而且在细胞氧化还原状态和叶黄素循环色素的分布方面,也表现出显着差异。这些差异可能是由于短毒素抑制了NTR。这项工作可能揭示了短毒素填补了K. brevis的生理作用。

更新日期:2018-01-03
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