Chemical reduction of graphene oxide (GO) is a simple and inexpensive method for the large-scale production of graphene-based materials. A suitable reducing agent, especially a green reductant, is in high demand for the production of reduced GO (RGO). Vancomycin, a glycopeptide antibiotic used to treat a variety of Gram-positive bacterial infections, was used to chemically reduce GO at a weak alkaline pH. As far as we know, this is the first report of reduction of GO by a glycopeptide antibiotic. The resulting vancomycin-decorated RGO (RGO-Van) was characterized by UV–visible adsorption and Raman spectroscopies, X-ray diffraction pattern and atomic force microscopy (AFM). The antibacterial effect of the RGO-Van suspension was investigated by the bacterial growth curves. The RGO-Van sheet can be fabricated into paper-like film through vacuum filtration. The antibacterial property of the as-obtained RGO-Van film was assessed by the inhibition zone test, and the bacterial adhesion assay. The antibacterial efficacy of the RGO-Van film was also verified by treatment of wound infection caused by Staphylococcus aureus (S. aureus) in a rat infection model.

化学还原氧化石墨烯（GO）是一种大规模生产石墨烯基材料的简单且廉价的方法。对于生产还原GO（RGO）的需求很高，特别是绿色还原剂。万古霉素是一种糖肽抗生素，用于治疗多种革兰氏阳性细菌感染，用于在弱碱性pH值下化学还原GO。据我们所知，这是糖肽抗生素减少GO的第一个报道。产生的装饰有万古霉素的RGO（RGO-Van）的特征在于紫外可见吸收和拉曼光谱，X射线衍射图和原子力显微镜（AFM）。通过细菌生长曲线研究了RGO-Van悬浮液的抗菌作用。可以通过真空过滤将RGO-Van片材制成纸状薄膜。通过抑制区试验和细菌粘附试验评估所获得的RGO-Van膜的抗菌性能。RGO-Van薄膜的抗菌功效还通过治疗由以下原因引起的伤口感染得到了验证：大鼠感染模型中的金黄色葡萄球菌（S. aureus）。