Metabolic syndrome is a cluster of metabolic alterations characterized by central obesity, dyslipidemia, elevated plasma glucose, insulin resistance (IR) and non-alcoholic fatty liver disease (NAFLD). In this study, a combined intervention of a lentil protein hydrolysate and a mixed training protocol was assessed in an animal experimental model of genetic obesity and metabolic syndrome. Thirty-two male obese and 32 lean Zucker rats were divided into eight different experimental groups. Rats performed a mixed exercise protocol or had a sedentary lifestyle and were administered a lentil protein hydrolysate or placebo. Daily food intake, weekly body weight gain, plasma parameters of glucose and lipid metabolisms, body composition, hepatic weight, total fat content and fatty acid profile, as well as gene expression of lipogenic and lipolytic nuclear transcription factors and their target genes were measured. Obese Zucker rats exhibited higher body and liver weight and fat content than did their lean counterparts. Such alterations were related to modifications in aerobic capacity, plasma biochemical parameters of glucose and lipid metabolisms, hepatic fatty acid profile and gene expression of nuclear transcription factors SREBP1c, PPARα, LXR and associated lipogenic and lipolytic enzymes. The interventions tested did not affect body weight gain but improved aerobic capacity, reduced hepatomegalia and steatosis associated with NAFLD and relieved the adverse effects produced by this condition in glucose and lipid metabolisms through the modulation in the expression of different genes involved in diverse metabolic pathways.

中文翻译：

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扁豆蛋白水解物和混合训练方案的联合干预对祖克大鼠脂质代谢和NAFLD肝标志物的影响†

代谢综合征是一组以中枢性肥胖，血脂异常，血浆葡萄糖升高，胰岛素抵抗（IR）和非酒精性脂肪肝（NAFLD）为特征的代谢改变。在这项研究中，在遗传性肥胖和代谢综合症的动物实验模型中评估了扁豆蛋白水解产物和混合训练方案的联合干预。将32只雄性肥胖大鼠和32只瘦Zucker大鼠分为八个不同的实验组。大鼠执行混合运动方案或久坐不动的生活方式，并给予小扁豆蛋白水解物或安慰剂。每日食物摄入量，每周体重增加，葡萄糖和脂质代谢的血浆参数，身体成分，肝重，总脂肪含量和脂肪酸状况，以及脂肪生成和脂解性核转录因子及其靶基因的基因表达。肥胖的祖克大鼠的脂肪，脂肪和脂肪含量均高于肥胖的祖克大鼠。这种改变与有氧能力，葡萄糖和脂质代谢的血浆生化参数，肝脂肪酸谱以及核转录因子SREBP1c，PPARα，LXR和相关的脂肪和脂肪分解酶的基因表达有关。测试的干预措施不影响体重增加，但改善了有氧运动能力，减少了与NAFLD相关的肝肿大和脂肪变性，并通过调节涉及多种代谢途径的不同基因的表达，减轻了这种情况对葡萄糖和脂质代谢产生的不利影响。