Eleven new compounds, including two quinone derivatives of bioxanthracene, conoideocrellones A (1) and B (2), two bioxanthracenes 3 and 4, four isocoumarins and isocoumarin glycosides 7–10, two phenolic compounds 16 and 17, and a diterpenoid compound, conoideocin A (18), were isolated from culture of the scale-insect pathogenic fungus Conoideocrella tenuis BCC 44534. Seventeen known compounds, compounds 5 and 6, ES-242-2 and its atropisomer, isocoumarins and isocoumarin glycosides 11–15, 3,4,6-trihydroxymellein, cis-4,6-dihydroxymellein, metarhizins A (19) and B (20), BR-050 (21), 5α,8α-epidioxy-24(R)-methylcholesta-6,22-dien-3β-ol, zeorin, and conoideocrellide A, were also isolated from this fungus. Structures of these compounds were elucidated by NMR and MS data analyses. Compound 4 was active against Plasmodium falciparum K1 (IC₅₀ 6.6 μg/mL), while it did not show cytotoxicity. Conoideocrellone A (1) and compounds 3 and 7 exhibited cytotoxic activity, while conoideocin A (18) showed broad range of biological activities including antimalarial, antibacterial, and cytotoxic activities.

11组新的化合物，包括bioxanthracene两个醌衍生物，conoideocrellones A（1）和B（2），两个bioxanthracenes 3和4，四个异香豆素和异香豆素苷7 - 10，两个酚化合物16和17，和二萜类化合物，conoideocin A（18），从该标度的昆虫致病性真菌的培养物中分离Conoideocrella细叶BCC 44534.十七已知的化合物，化合物5和6，ES-242-2和其阻转异构体，异香豆素和异香豆素苷11 - 15，3,4,6- trihydroxymellein，顺式-4,6- dihydroxymellein，metarhizins A（19）和B（20），BR-050（21），5 α，8 α -epidioxy-24（[R）-methylcholesta- 6,22二烯-3- β醇，zeorin，和conoideocrellide A，也从这种真菌中分离。通过NMR和MS数据分析阐明了这些化合物的结构。化合物4对恶性疟原虫K1具有活性（IC _50为6.6μg/ mL），而没有细胞毒性。香豆烯酮A（1）以及化合物3和7表现出细胞毒活性，而香豆素A（18）表现出广泛的生物学活性，包括抗疟疾，抗菌和细胞毒活性。