Abstract In this work, SrTiO3 nanoparticles (SrTiO3NPs), a novel and effective perovskite-type material, are synthesized to modify electrode for the development of sensitive enzymatic electrochemical biosensor applications. The electrochemical behavior of glucose oxidase (GOx) immobilized on SrTiO3NPs-modified glassy carbon electrode is investigated. Scanning electron microscopy and cyclic voltammetry are used to characterize the morphology and assay property of different modified electrodes. Results illustrate that SrTiO3NPs possess large surface area and apparently enhance the direct electron transfer between GOx and modified electrode. The SrTiO3NPs-based enzyme biosensor shows a high sensitivity of 15.6 mA·M− 1·cm− 2, wide linear range from 0.01 mM to 1.2 mM, and a low detection limit of 3 μM (S/N = 3). Furthermore, the resultant glucose biosensor has excellent selectivity, acceptable repeatability, practicality and stability. The perovskite SrTiO3NPs provide a very attractive and potential electrode material to develop electrochemical biosensors.

中文翻译：

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用于敏感电化学生物传感应用的钙钛矿型 SrTiO 3 纳米颗粒的合成

摘要 在这项工作中，合成了一种新型有效的钙钛矿型材料 SrTiO3 纳米粒子 (SrTiO3NPs) 来修饰电极，以开发灵敏的酶电化学生物传感器应用。研究了固定在 SrTiO3NPs 修饰的玻碳电极上的葡萄糖氧化酶 (GOx) 的电化学行为。扫描电子显微镜和循环伏安法用于表征不同修饰电极的形态和测定性能。结果表明，SrTiO3NPs 具有大的表面积，明显增强了 GOx 和修饰电极之间的直接电子转移。基于 SrTiO3NPs 的酶生物传感器显示出 15.6 mA·M− 1·cm− 2 的高灵敏度，0.01 mM 到 1.2 mM 的宽线性范围，以及 3 μM (S/N = 3) 的低检测限。此外，所得葡萄糖生物传感器具有优良的选择性、可接受的重复性、实用性和稳定性。钙钛矿 SrTiO3NPs 为开发电化学生物传感器提供了一种非常有吸引力和潜在的电极材料。