A method is presented for synthesizing and characterizing core/shell nanogels based around poly(N-isopropyl methacrylamide) (PNIPMAAm). The effectiveness of the sequential addition reaction scheme was determined for its impact on temperature response, glass transition temperature, and details of polymer structure as revealed by ¹H NMR spectra. PNIPMAAm cores coated with poly(tert-butyl methacrylate) (PTBMA), poly(ethylene glycol phenyl acrylate) (PEGPhA), and poly(phenyl methacrylate) (PPhMA) were characterized for structure and effectiveness as carriers for the model chemotherapeutic Doxorubicin (DOX). Swelling studies showed that the core/shell polymerization significantly decreases the collapse, though had limited impact on the lower critical solution temperature (LCST) of PNIPMAAm. Coating with PEGPhA did impart large variability in the particle size. Proton NMR and DSC confirmed the core/shell structure for all samples; however it proved that PPhMA was less effective at coating the PNIPMAAm nanogel. The core/shell nanogels were then characterized for their application as drug delivery vehicles using DSC, partition coefficient, and drug release studies with DOX. These studies showed that coating PNIPMAAm with PTBMA developed a more effective drug delivery vehicle for hydrophobic drugs like DOX.

提出了一种基于聚（N-异丙基甲基丙烯酰胺）（PNIPMAAm）的核/壳纳米凝胶的合成和表征方法。通过¹ H NMR光谱揭示了顺序加成反应方案对温度响应，玻璃化转变温度和聚合物结构细节的影响，确定了其有效性。涂有聚（PNIPMAAm芯叔表征了甲基丙烯酸丁酯（PTBMA），聚乙二醇丙烯酸丁酯（PEGPhA）和聚甲基丙烯酸苯酯（PPhMA）的结构和有效性，作为模型化阿霉素（DOX）的载体。溶胀研究表明，核/壳聚合显着降低了塌陷，尽管对PNIPMAAm的较低临界溶液温度（LCST）的影响有限。PEGPhA涂层确实赋予了粒径很大的可变性。质子NMR和DSC证实了所有样品的核/壳结构。然而，事实证明，PPhMA在包覆PNIPMAAm纳米凝胶时效果较差。然后使用DSC，分配系数和用DOX进行药物释放研究，对核/壳纳米凝胶的应用作了表征。