Abstract A method is presented for optimizing the cooling strategy and seed loading simultaneously. Focused beam reflectance measurement (FBRM) was used to determine the approximating optimal cooling profile. Using these results in conjunction with constant growth rate assumption, modified Mullin-Nyvlt trajectory could be calculated. This trajectory could suppress secondary nucleation and has the potential to control product’s polymorph distribution. Comparing with linear and two step cooling, modified Mullin-Nyvlt trajectory have a larger size distribution and a better morphology. Based on the calculating results, the optimized seed loading policy was also developed. This policy could be useful for guiding the batch crystallization process.

中文翻译：

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通过批量结晶的 FBRM 分析优化冷却策略和晶种

摘要 提出了一种同时优化冷却策略和种子加载的方法。聚焦光束反射测量 (FBRM) 用于确定近似的最佳冷却曲线。将这些结果与恒定增长率假设结合使用，可以计算修改后的 Mullin-Nyvlt 轨迹。这种轨迹可以抑制二次成核，并有可能控制产品的多晶型分布。与线性和两步冷却相比，改进的 Mullin-Nyvlt 轨迹具有更大的尺寸分布和更好的形态。根据计算结果，还制定了优化的种子加载策略。该策略可用于指导分批结晶过程。