当前位置: X-MOL 学术Carbohydr. Polym. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Photopolymerized Maleilated Chitosan/Thiol-terminated Poly (vinyl alcohol) hydrogels as Potential Tissue Engineering Scaffolds
Carbohydrate Polymers ( IF 11.2 ) Pub Date : 2018-01-03 , DOI: 10.1016/j.carbpol.2018.01.009
Yingshan Zhou , Shuyan Zhao , Can Zhang , Kaili Liang , Jun Li , Hongjun Yang , Shaojin Gu , Zikui Bai , Dezhan Ye , Weilin Xu

Photocrosslinkable hydrogels composed of natural materials exhibit great application potential in tissue engineering scaffolds. However, weak formation and poor mechanical property can usually be a limitation. Herein, the photo-clickable thiol-ene hydrogels based chitosan were synthesized using photopolymerization of maleic chitosan (MCS) and thiol-terminated poly (vinyl alcohol) (TPVA) in the presence of a biocompatible photoinitiator. Rheological property and absorbing behavior of the MCS/TPVA hydrogels could be tailored by varying the amount of TPVA in the feed. There was strong intermolecular hydrogen bonding between the molecules of MCS and TPVA. Notably, the MCS/TPVA hydrogel (MT-3) exhibited rapid gelation behavior (<120 s), improved stiff (G' = ∼5500 Pa) and compressive strength (0.285 ± 0.014 MPa), which were important for hydrogel scaffolds, especially for injectable hydrogel scaffolds. Photocrosslinked MCS/TPVA hydrogels was cytocompatible and could promote the L929 cells attachment and proliferation, showing their potential as tissue engineering scaffolds.



中文翻译:

光聚合马来酰化壳聚糖/巯基封端的聚乙烯醇水凝胶作为潜在的组织工程支架

由天然材料组成的可光交联水凝胶在组织工程支架中显示出巨大的应用潜力。但是,薄弱的成型和较差的机械性能通常是一个限制。在此,在生物相容性光引发剂的存在下,使用马来酸壳聚糖(MCS)和硫醇封端的聚(乙烯醇)(TPVA)的光聚合来合成基于光可点击的硫醇-烯水凝胶的壳聚糖。可以通过改变饲料中TPVA的量来调整MCS / TPVA水凝胶的流变性和吸收性能。MCS和TPVA分子之间存在强大的分子间氢键。值得注意的是,MCS / TPVA水凝胶(MT-3)表现出快速的凝胶化行为(<120 s),改善的刚度(G'=约5500 Pa)和抗压强度(0.285±0.014 MPa),对于水凝胶支架,特别是对可注射的水凝胶支架而言,它们非常重要。光交联的MCS / TPVA水凝胶具有细胞相容性,可以促进L929细胞的附着和增殖,显示出其作为组织工程支架的潜力。

更新日期:2018-01-03
down
wechat
bug