In this investigation, a variety of innovative pH-sensitive polymers consisting of Chinese quince seed gum (CQSG) and poly (N,N-diethylacryl amide-co-methacrylic acid) were synthesized via free radical polymerization for controlled drug delivery. The resultant hydrogel polymers were characterized by scanning electron microscopy and X-ray diffraction, analyzed by Fourier-transform infrared spectroscopy, and confirmed with thermogravimetry. Results suggested the hydrogel polymers were composed of CQSG chains physically entangled in poly (N,N-diethylacryl amide-co-methacrylic acid) networks. Swelling properties of these hydrogels were strongly affected by the contents of CQSG and crosslinkers. The drug delivery applications of the hydrogels were evaluated using bovine serum albumin (BSA) as a model drug in vitro release. It was determined that BSA release from the hydrogels was pH-sensitive under simulated gastrointestinal conditions. All of these attributes imply that the new proposed CQSG/poly (N,N-diethylacryl amide-co-methacrylic acid) hydrogel polymers can be used as a good medium for oral delivery of proteinaceous drugs.

在这项研究中，由木瓜籽胶（CQSG）和聚（N，N-二乙基丙烯酰胺-共-甲基丙烯酸）组成的各种创新的pH敏感聚合物是通过自由基聚合合成的，用于控制药物的输送。通过扫描电子显微镜和X射线衍射对所得的水凝胶聚合物进行表征，通过傅里叶变换红外光谱法进行分析，并通过热重分析进行确认。结果表明，水凝胶聚合物由物理缠结在聚（N，N）中的CQSG链组成。-二乙基丙烯酸酰胺-共-甲基丙烯酸）网络。这些水凝胶的溶胀特性受CQSG和交联剂含量的强烈影响。使用牛血清白蛋白（BSA）作为体外模型药物评估了水凝胶的药物递送应用。已确定在模拟胃肠道条件下，BSA从水凝胶中的释放对pH敏感。所有这些属性暗示新提出的CQSG /聚（N，N-二乙基丙烯酰胺-共-甲基丙烯酸）水凝胶聚合物可以用作蛋白质药物口服递送的良好介质。