The first total syntheses of five natural eremophilane-type sesquiterpenoids were achieved in 4–12 steps via a common synthetic intermediate. The syntheses feature a double Michael addition, Robinson annulation, α-enolization of an unsaturated ketone, and Pd-catalyzed Suzuki coupling reaction to install the side chain. This synthetic strategy could be easily extended to other eremophilane-type sesquiterpenoids with similar bicyclic skeletons.

中文翻译：

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五种天然艾草双倍型倍半萜的全合成†

通过一个普通的合成中间体，在4至12个步骤中完成了5种天然艾草双酚倍半萜类化合物的第一个总合成。合成具有双迈克尔加成反应，罗宾逊环化，不饱和酮的α-烯丙基化和Pd催化的Suzuki偶联反应以安装侧链。这种合成策略可以很容易地扩展到其他具有类似双环骨架的天青石型倍半萜。