A systematic analysis of all synthetic and chemoenzymatic methodologies for the preparation of aminoglycosides for a variety of applications (therapeutic and agricultural) reported in the scientific literature up to 2017 is presented. This comprehensive analysis of derivatization/generation of novel aminoglycosides and their conjugates is divided based on the types of modifications used to make the new derivatives. Both the chemical strategies utilized and the biological results observed are covered. Structure-activity relationships based on different synthetic modifications along with their implications for activity and ability to avoid resistance against different microorganisms are also presented.

中文翻译：

---

新型氨基糖苷类药物制备化学策略及其生物活性的综合评述

对截至 2017 年科学文献中报道的用于各种应用（治疗和农业）的氨基糖苷类制备的所有合成和化学酶方法进行了系统分析。这种新型氨基糖苷类及其缀合物的衍生化/生成的综合分析根据用于制造新衍生物的修饰类型进行划分。涵盖了所使用的化学策略和观察到的生物学结果。还介绍了基于不同合成修饰的结构-活性关系及其对活性和避免对不同微生物产生耐药性的能力的影响。