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Delivery of Hydrophobic Anticancer Drugs by Hydrophobically Modified Alginate Based Magnetic Nanocarrier
Industrial & Engineering Chemistry Research ( IF 4.2 ) Pub Date : 2018-01-16 00:00:00 , DOI: 10.1021/acs.iecr.7b04050
Ali Pourjavadi 1 , Shiva Sadat Amin 1 , Seyed Hassan Hosseini 2
Affiliation  

Since most of the anticancer drugs have low solubility in water, the clinical use of them is limited unless by some modification the solubility increases or the drug is carried with a soluble compartment. To solve this problem, we prepared a magnetic nanocarrier with a hydrophobic surface based on oleic acid chains in which hydrophobic drug molecules such as doxorubicin hydrochloride (DOX) and paclitaxel (PTX) are easily adsorbed onto the surface. Since the drug molecules are physically adsorbed on the surface, large amounts of DOX (282 mg·g–1) and PTX (316 mg·g–1) were immobilized onto the nanocarrier. Then, the surface of the drug loaded magnetic core was covered by a smart pH-sensitive shell based on sodium alginate. The alginate shell around the magnetic core increased the stability and biocompatibility of the drug loaded nanocarrier. The results of the drug release profile showed that the drug molecules were released faster in acidic medium than in the neutral medium. The MTT assay of the nanocarrier showed low toxicity toward MCF-7 and HeLa cells, while the drug loaded nanocarrier had high toxicity, even higher than the free drugs. Owing to these advantages, the resulting nanocarrier exhibits a promising potential for delivery of hydrophobic drug molecules in clinical applications.

中文翻译:

疏水修饰的藻酸盐基磁性纳米载体对疏水性抗癌药物的传递

由于大多数抗癌药物在水中的溶解度很低,因此除非经过某些修改溶解度增加或药物带有可溶区室,否则它们的临床应用受到限制。为了解决该问题,我们基于油酸链制备了具有疏水表面的磁性纳米载体,其中疏水药物分子如盐酸阿霉素(DOX)和紫杉醇(PTX)容易吸附到表面。由于药物分子物理吸附在表面上,因此大量的DOX(282 mg·g –1)和PTX(316 mg·g –1)被固定在纳米载体上。然后,载有药物的磁芯表面被基于藻酸钠的智能pH敏感外壳覆盖。磁芯周围的藻酸盐外壳提高了载药纳米载体的稳定性和生物相容性。药物释放曲线的结果表明,药物分子在酸性介质中的释放比在中性介质中的释放更快。纳米载体的MTT分析显示对MCF-7和HeLa细胞低毒性,而载药纳米载体具有高毒性,甚至高于游离药物。由于这些优点,所得的纳米载体在临床应用中显示出有希望的疏水药物分子的递送潜力。
更新日期:2018-01-16
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