Herein, we report that acridine intermediates 5 were obtained from the reduction of nitro acridine derivatives 4, which were synthesized via condensation of dimedone, p-nitrobenzaldehyde with 4-amino-N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)benzamide, respectively. Then acridine sulfonamide/carboxamide (7a–i) compounds were synthesized by reaction of amino acridine 5 with sulfonyl chlorides and carbamoyl chlorides. The new compounds were characterized by melting points, FT-IR, ¹H NMR, ¹³C NMR and HRMS analyzes. The evaluation of in vitro test of the synthesized compounds against hCA I, II, IV and VII showed that some of them are potent inhibitors. Among them, compound 7e showed the most potent activity against hCA II with a K_I of 7.9 nM.

在此，我们报道that啶中间体5是从硝基a啶衍生物4的还原中获得的，硝基dim啶衍生物是通过将二甲酮，对硝基苯甲醛与4-氨基-N-（5-氨磺酰基-1,3,4-噻二唑-缩合而合成的）2-基）苯甲酰胺，分别。然后通过氨基of啶5与磺酰氯和氨基甲酰氯的反应合成a啶磺酰胺/羧酰胺（7a – i）化合物。新化合物的特征在于熔点，FT-IR，¹ H NMR，¹³C NMR和HRMS分析。对合成的化合物针对hCA I，II，IV和VII的体外测试的评估表明，其中一些是有效的抑制剂。其中，化合物7e对hCA II的活性最强，K _I为7.9 nM。