There are no approved medications for the treatment of Marburg or Ebola virus infection. In two previous articles (Martin et al., 2016, Martin et al., 2017), we reviewed surface glycoprotein and replication proteins structure/function relationship to decipher the molecular mechanisms of filovirus life cycle and identify antiviral strategies. In the present article, we recapitulate knowledge about the viral proteins involved in filovirus assembly and budding. First we describe the structural data available for viral proteins associated with virus assembly and virion egress and then, we integrate the structural features of these proteins in the functional context of the viral replication cycle. Finally, we summarize recent advances in the development of innovative antiviral strategies to target filovirus assembly and egress. The development of such prophylactic or post-exposure treatments could help controlling future filovirus outbreaks.

没有批准用于治疗马尔堡或埃博拉病毒感染的药物。在之前的两篇文章中（Martin et al。，2016，Martin et al。（2017年），我们综述了表面糖蛋白和复制蛋白的结构/功能关系，以阐明丝状病毒生命周期的分子机制并确定抗病毒策略。在本文中，我们概述了有关丝状病毒装配和萌芽的病毒蛋白的知识。首先，我们描述了与病毒装配和病毒粒子流出相关的可用于病毒蛋白的结构数据，然后，我们在病毒复制周期的功能范围内整合了这些蛋白的结构特征。最后，我们总结了针对丝状病毒装配和出口的创新抗病毒策略的最新进展。这种预防或暴露后治疗方法的发展可能有助于控制未来的丝状病毒爆发。