Abstract Hydrogel-based wound dressings are one of the most promising materials in wound care, fulfilling important dressing requirements, including: (a) keeping the wound moist whilst absorbing extensive exudate, (b) adhesion-free coverage of sensitive underlying tissue, (c) pain reduction through cooling and (d) a potential for active intervention in the wound healing process. Although numerous hydrogel-based dressings are already on the market, new wound care treatment options are urgently required to address the growing number of severe, acute and chronic wounds experienced by today’s aging society. High cost, safety concerns surrounding the use of drugs and allogeneic/xenogeneic materials, and issues specific to hydrogels, such as lack of mechanical stability, are impeding clinical implementation of many novel approaches. To meet clinical needs, the development of new hydrogel wound dressings that overcome these drawbacks would be desirable. This review provides a broad overview of recent progress – commercial and scientific – in the field of bioactive hydrogel wound dressings. A variety of approaches to bioactive wound healing, such as bioactive dressing materials, use of antimicrobial agents, inclusion of biological signaling molecules like growth factors, and incorporation of seeded stem cells, are considered and critically evaluated.

中文翻译：

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用于急性和慢性伤口生物活性治疗的水凝胶伤口敷料

摘要 基于水凝胶的伤口敷料是伤口护理中最有前途的材料之一，满足重要的敷料要求，包括：(a) 保持伤口湿润，同时吸收大量渗出液，(b) 无粘连覆盖敏感的底层组织，(c) ) 通过冷却减轻疼痛和 (d) 积极干预伤口愈合过程的潜力。尽管市场上已经有许多基于水凝胶的敷料，但迫切需要新的伤口护理治疗方案来解决当今老龄化社会所经历的越来越多的严重、急性和慢性伤口。围绕使用药物和同种异体/异种材料的高成本、安全问题以及水凝胶特有的问题，例如缺乏机械稳定性，正在阻碍许多新方法的临床实施。为了满足临床需求，需要开发克服这些缺点的新型水凝胶伤口敷料。这篇综述对生物活性水凝胶伤口敷料领域的最新进展——商业和科学——进行了广泛的概述。生物活性伤口愈合的各种方法，例如生物活性敷料材料、抗菌剂的使用、生物信号分子（如生长因子）的包含以及种子干细胞的掺入，都被考虑并严格评估。