In current study we present two polysaccharides, STRP1 and STRP2, purified from Sophorae tonkinensis Radix via column chromatography. Structural analyses indicated that STRP1 and STRP2 were consisted of mannose, rhamnose, glucuronic acid, glucose, galactose and arabinose in a similar molar ratio with main backbones of (1 → 3)-linked-α-D-Gal and (1 → 4)-linked-α-D-Glc, while average molecular weights were 1.30 × 10⁴ and 1.98 × 10⁵ Da, respectively. We observed a strong chelating ability on ferrous ions; substantial radical scavenging activities on DPPH, hydroxyl and superoxide anion radicals in vitro; and significant attenuation on acetaminophen-induced hepatic oxidative damage in mice for STRP1 and STRP2. The promising data on these polysaccharides showcase the need to further develop novel natural antioxidant and liver-protecting drugs.

在目前的研究中，我们提出两种多糖，STRP1和STRP2，从纯化的山豆根苦参沙参经由柱色谱法。结构分析表明，STRP1和STRP2由甘露糖，鼠李糖，葡糖醛酸，葡萄糖，半乳糖和阿拉伯糖组成，摩尔比与（1→3）-连接的α-D-Gal和（1→4）的主要骨架相似。 -α-D-Glc，平均分子量为1.30×10 ⁴和1.98×10 ⁵ 分别。我们观察到对亚铁离子具有很强的螯合能力；在体外对DPPH，羟基和超氧阴离子自由基具有显着的自由基清除活性；并显着减轻对乙酰氨基酚引起的小鼠对STRP1和STRP2的肝氧化损伤。这些多糖有希望的数据表明需要进一步开发新型的天然抗氧化剂和保护肝脏的药物。